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Zaine comments on Hoping to start a discussion about overcoming insecurity - Less Wrong
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Perhaps I've misunderstood the post, but it seems like they are doing a variant of Cognitive Behavioural Therapy; id est, they are identifying problem thought areas and attempting to change them during activation.
Yes. Activation is the key. The synapses that code the learned emotional responses have a period after which they have been activated during which they can be changed. If no disconfirming or contradictory experience takes place they will be re-consolidated. But if a disconfirm experience takes place in that window they will not. That is the theory and there is some good animal research to support it.
Note that this period is extremely time sensitive, and, depending upon when changes occur, determines whether the strength of the connection will be increased or decreased. For anyone interested in a technical explanation of this theory of memory, vide - particularly the sky blue side bars on the left. Although not believed the whole territory, it, to about half of convention-going neuroscientists, comprises a large part of the current map.