What caused you to invoke "Science!" in the sense you did here at all? It seems to hint a confusion about epistemology and a status move. It is easy to come up with scenarios where we are tasked with making predictions about things where science fails and do quite well. See this article by Eliezer.
I disagree. You know how scientific method works, right? You make an observation, create a model, make another observation and see how well your model fits. With a unique phenomena you only have one observation.
The whole anthropic principle thing just annoys me because it seems to stem from a confusion. People can certainly imagine a lot of universes without people. So they compare it to the real world and say it is fine-tuned. But this is a misapplication of scientific method. What you imagine is not an observation. You can't invent different laws of phys...
A post by Nick Land who some of you are probably already following either on his blog Outside In or at Urban Future.