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Crux comments on Where I've Changed My Mind on My Approach to Speculative Causes - Less Wrong
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Certainly it seems to be the case that people have a lot harder of a time changing their mind once they get past their 40s or 50s, but at the same time I have met a few people closing in on their 70s who have made radical changes to their lives and their thinking. It's not impossible; just way more difficult.