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Eliezer_Yudkowsky comments on Torture vs Dust Specks Yet Again - Less Wrong
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Givewell does not think you can save one African from starving with $2000. You might be able to save one child from dying of malaria via insecticide-treated mosquito bednets. But this of course will not be the optimal use of $2K even on conventional targets of altruism; well-targeted science research should beat that (where did mosquito nets come from?).