would you seriously, given the choice by Alpha, the Alien superintelligence that always carries out its threats, give up all your work, and horribly torture some innocent person, all day for fifty years in the face of the threat of a 3^^^3 insignificant dust specks barely inconveniencing sentient beings? Or be tortured for fifty years to avoid the dust specks?

Likewise, if you were faced with your Option 1: Save 400 Lives or Option 2: Save 500 Lives with 90% probability, would you seriously take option 2 if your loved ones were included in the 400? I wouldn't. Faced with statistical people I'd take option 2 every time. But make Option 1: Save 3 lives and those three lives are your kids or option 2: Save 500 statistical lives with 90% probability I don't think I'd hesitate to pick my kids.

In some sense, I'm already doing that. For the cost of raising three kids, I could have saved something like 250 statistical lives. So I don't know that our unwillingness to torture a loved one is a good argument against the math of the dust specks.