I didn't mean it literally. I meant, everything on which we base our long-term plans.

For example:

You go to school, save up money, try to get a good job, try to advance in your career... on the belief that you will find the results rewarding. However, this is pretty easily dismantled if you're not a life-extensionist and/or cryonicist (and don't believe in an afterlife). All it takes is for you to have the realization that

1) If your memory of an experience is erased thoroughly enough (and you don't have access to anything external that will have been altered by the experience) then the experience might as well have not happened. Or insofar that it altered you through some other way than your memories, is interchangeable with any other experience that would have altered you in the same way.

2) In the absence of an afterlife, if you die all your memories get permanently deleted shortly after, and you have no further access to anything influenced by your past experiences including yourself. Therefore, death robs you of your past, present, and future making it as if you had never lived. Obviously other people will remember you for a while, but you will have no awareness of that because you will simply not exist.

Therefore, no matter what you do, it will get cancelled out completely. The way around it is to make a superhuman effort at doing the not-literally-prohibited-by-physics-as-far-as-we-know kind of impossible by working to make cryonics, anti-aging, uploading, or AI (which presumably will then do one of the preceding three for you) possible. But perhaps at an even deeper level our idea of what it is these courses of action are attempting to preserve is itself self-contradictory.

Does that necessarily discredit these courses of action?