ShannonFriedman comments on The Anti-Placebo Effect - Less Wrong
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Yes, a lot of it has do to with having the parts of your mind that are action oriented not in alignment with the ones that want to have fun. If you're in that state for a long time, or in any way that ingrains the patterns hard, eventually you get to more extreme states like lack of interest in anything.
I use non-medication techniques to get people out of these states as my profession. You might find this audio helpful.