You may feel better about being audacious if you do an explicit cost-of-living calculation given the rent and price differential. If you see that maintaining the same standard of living is going to cost you 80k, then 100k stops seeming like a huge number.

It's also true that there is only epsilon chance of screwing yourself. Nobody is going to reject you because the expected salary number you suggested was too high; it makes no sense. You could suggest 150k and the only bad thing that will happen is you might only get offered 120k.