So there are two distinct arguments being made: one is a resource allocation argument (it would be better to spend fewer resources right now on things like particle physics) and the second argument is that in many fields one can still make discoveries with few resources. The first argument may have some validity. The second argument ignores how much work is required in most cases. Yes, one can do things like investigate specific vitamin metabolism issues. But if one is interested in say synthesizing new drugs, or investigating how those drugs would actually impact people that requires large scale experiments.
The fact that most work in biology relies on experiments suggests that there are not enough people doing good theoretical work in the field it.
That's not what is going on here. The issue is that biology is complicated. Life doesn't have easy systems that have easy theoretical underpinnings that can be easily computed. There are literally thousands of distinct chemicals in a cell interacting, and when you introduce a new one, even if you've designed it to interact with a specific receptor, it will often impact others. And even if it does only impact the receptor in question, how it does so will matter. You are dealing with systems created by the blind-idiot god.
You are defending a way of doing biology that plagued by various problems. It's a field where people literally believe that they can perceive more when they blind themselves.
There are huge issues in the theoretically underpinning of that approach because the people in the system are too busy writing research that doesn't replicate for top tier journals that requires expensive equipment instead of thinking more about how to approach the field.
For those who haven't heard, NIH and NSF are no longer processing grants, leading to many negative downstream effects.
I've been directing my attention elsewhere lately and don't have anything informative to say about this. However, my uninformed intuition is that people who care about effective altruism (research in general, infrastructure development, X-risk mitigation, life-extension...basically everything, actually) or have transhumanist leanings should be very concerned.
The consequences have already been pretty disastrous. To provide just one, immediate example, the article says that the Center for Disease Control and Prevention has shut down. I think that this is almost certain to directly cause a nontrivial number of deaths. Each additional day that this continues could have huge negative impact down the line, perhaps delaying some key future discoveries by years. This event *might* be a small window of opportunity to prevent a lot of harm very cheaply.
So the question is:
1) Can we do anything to remedy the situation?
2) If so, is it worth doing it? (Opportunity costs, etc)