Given that both are competent and Bob doesn't have strong priors X should be about the same as Y.
Why? X is P(results >= what we saw | effect = 0), whereas Y is P(effect < costs | results = what we saw). I can see no obvious reason those would be similar, not even if we assume costs = 0; p(results = what we saw | effect = 0) = p(effect = 0 | results = what we saw) iff p_{prior}(result = what we saw) = p_{prior}(effect = 0) (where the small p's are probability densities, not probability masses), but that's another story.
Why?
You have two samples: one was given the drug, the other was given the placebo. You have some metric for the effect you're looking for, a value of interest.
The given-drug sample has a certain distribution of the values of your metric which you model as a random variable. The given-placebo sample also has a distribution of these values (different, of course) which you also model as a random variable.
The statistical questions are whether these two random variables are different, in which way, and how confident you are of the answers.
For simple question...
For those who haven't heard, NIH and NSF are no longer processing grants, leading to many negative downstream effects.
I've been directing my attention elsewhere lately and don't have anything informative to say about this. However, my uninformed intuition is that people who care about effective altruism (research in general, infrastructure development, X-risk mitigation, life-extension...basically everything, actually) or have transhumanist leanings should be very concerned.
The consequences have already been pretty disastrous. To provide just one, immediate example, the article says that the Center for Disease Control and Prevention has shut down. I think that this is almost certain to directly cause a nontrivial number of deaths. Each additional day that this continues could have huge negative impact down the line, perhaps delaying some key future discoveries by years. This event *might* be a small window of opportunity to prevent a lot of harm very cheaply.
So the question is:
1) Can we do anything to remedy the situation?
2) If so, is it worth doing it? (Opportunity costs, etc)