It definitely does, i.e. the ion gates and receptors and such are molecular complexes, and most of the information is virtually certain to be in the states of molecules (shapes for those that can be in either shape, adhesion of molecules, etc etc), the sort of stuff that will get irreversibly lost when proteins denature due to either high salinity or "cryoprotectants".
I'm skeptical that the brain could be this delicate in operation and still work as robustly as it does.
edit: I suppose it's plausible that memories could be stored this way if they're done so redundantly, in which case a systematic unraveling of proteins might destroy them in a way that normal wear-and-tear wouldn't.
"Virtually certain" seems like overreaching as far as I'm aware though - is this the standard point of view among biologists?
In the past, the Cryonics Institute has had a policy that said that they would not accept anyone who is not a member. This has changed. The policy now is that someone who has full legal authority over your body can sign you up after you die. It costs $36,250 to be frozen if you are not signed up, which is more expensive. They also will not do anything until you have been on dry ice for 2 weeks after they have been contacted, so not being a member is more risky.
This is very important news for anyone who is currently cryocrastinating. It means that you can drastically increase your chances of survival without filling out any forms. All you have to do is tell a loved one you want to be frozen upon death, and that you would like them to take responsibility for making sure this happens. This takes literally 30 seconds. Do it now!
This news might also be a reason to not sign up right away, if you think something better (like radical life extension or uploading) will come along in your lifetime. We should discuss this in the comments.
Edit: The general consensus of this discussion is that this is a really bad reason not to sign up for cryonics.