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Lumifer comments on Dr. Jubjub predicts a crisis - Less Wrong
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Well, it's up to you to decide how much the uncertainty of outcome should influence your willingness to do something. It's OK to think it's worthwhile to follow a certain path even if you don't know where would it ultimately lead.
"Uncertainty" is different than "no clue." Or maybe I'm assuming too much about what you mean by "no clue" - to my ear it sounds like saying we have no basis for action.
Large amounts of uncertainty including the paradoxical possibility of black swans == no clue.
You have no basis for action if you are going to evaluate your actions on the basis of consequences in a hundred years.