If it turns out that the whole MIRI/LessWrong memeplex is massively confused, what would that look like?

A few that come to mind:

• Some religious framework being basically correct. Humans having souls, an afterlife, etc.
• Antinatalism as the correct moral framework.
• Romantic ideas of the ancestral environment are correct and what feels like progress is actually things getting worse.
• The danger of existential risk peaked with the cold war and further technological advances will only hasten the decline.