(1) You write that 'the Supreme Court has gotten the verdict it wanted.' Why does the Supreme Court want to convict Sollecito and Knox?

Presumably, because they watch the same TV shows as everyone else in Italy, and are convinced that Sollecito and Knox are bad characters, and are furthermore convinced that the Italian public thinks that Sollecito and Knox are bad characters, thus allowing them to play the role of "heroes" doing their duty and standing up for "justice".

(2) In the room murder was committed, no DNA evidence pertaining to Knox and Sollecito was found. How does the prosecution explain that only one assailant (Guede) left traces of DNA but the two others left no such traces?

Firstly, of course, they claim that the bra clasp DNA counts as a trace left in the room by Sollecito. Secondly, the original lead prosecutor, Giuliano Mignini, at one point speculated that Knox directed the violence from outside the room.

(3) It is said that the evidence shows that Kercher was killed by multiple people. What is your take on this?

It's just plain wrong, and entirely motivated by the desire to imply that Knox and Sollecito were involved. It's possible that Guede had one or more accomplices (of whom no trace has been identified), but parsimony argues against it.

(4) Perhaps most basically, how did Knox and Sollecito get implicated in this crime? I mean there were a lot of witnesses being questioned but how did the police/investigators somehow get the idea that Knox and Sollecito were suspects?

They were convenient, vulnerable (no lawyers, unlike the other housemates), and unaware of the specific way in which the investigators apparently expected all innocent humans to behave in such a situation. In short, easy targets for an impatient, quasi-panicked police force in need of a quick "resolution" to the case.