Aside from the regrettable anti-death quote that crowns the All Time list, most of the top quotes on both seem to be directly about epistemic rationality.
Although I agree that the anti-death joke is overrated, it can be read as a general statement on instrumental rationality, a recognition of the fact that Type I and Type II errors can have very asymmetric consequences. The question of "what hypothesis should I act on when under great uncertainty" often boils down to "which action is easier to correct if/when I turn out to be wrong later". Under this reading the joke isn't "death really sucks amirite?" but rather "if I'm alive by mistake it's much easier to change that than if I'm dead by mistake".
Another month has passed and here is a new rationality quotes thread. The usual rules are: