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RomeoStevens comments on Lifestyle interventions to increase longevity - Less Wrong
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For many smaller doses do work better than larger doses, though I don't have the cite handy. Better to start too small and work up than the other way around IMO. When I took large doses I had negative side effects.
Does the word "cite" mean that you have seen a controlled study claiming that smaller doses are more effective than large doses, and not just anecdotes?
Yes. or at the very least there were issues with side effects and tolerance building.
This is a press release, but might be a pointer in the direction of the study.
this is the insomnia study for that press release