Hmmm. It would be sufficient for the maniacal laughter to take place; technically, the villainy is unnecessary, as long as the necessary parts of the brain can be fooled.

One way to do this would be with a computer game; playing civilisation (for example), betraying your computer-player allies, and then laughing maniacally about it.

Alternatively, for more of a challenge (in case overcoming difficult opposition turns out to be a necessary element), one could play a game against human players (Diplomacy might work well here) and laugh maniacally if one achieves victory. (Since the game is structured in such a way that at least one player must eventually achieve victory, someone will have the opportunity to gain the health benefits of the maniacal laughter; one may have additional opportunities during the game to laugh maniacally as well).