Obvious example: selling cigarettes.
The cigarette is the deadliest artefact in the history of human civilisation. [...] Cigarettes cause about one death per million smoked³⁵ with a latency of about 25 years, which is why the 6 trillion smoked in 1990 will cause about 6 million deaths in 2015. [...] One-third or one-quarter of those deaths will be from lung cancer; about one every 15 or 20 s. [...] Cigarette companies make about a penny in profit for every cigarette sold, or about US$10 000 for every million cigarettes purchased. Since there is one death for every million cigarettes sold (or smoked), a tobacco manufacturer will make about US$10 000 for every death caused by their products.
Presumably there are even worse legal ways to make a profit, but this sets a nicely unambiguous lower bound, I think.
A lot of industries are going to look really bad if you only score one side of the ledger. Given that a huge number of people continue to smoke and enjoy it, despite knowing the negative implications for their health it seems reasonable to assume that tobacco companies supply the world with a great deal of utility, in addition to the lung cancer.
This is an offshoot of a thread I made earlier, but which wasn't eliciting the sort of responses I'd hoped for.
So let me pose a clearer question with less potential to get people on watchlists.
What legal ways of making a profit are the most anti-altruistic, the most damaging to society, the opposite of effective altruism in result.
I am using utility loosely. The answers need not be given from a utilitarian perspective at all, but instead merely deal with any means of making a profit that seems to you clearly wretched, and such that the world would be better if nobody participated in it.
I'd also like to emphasize that these things should be legal. There are some obviously wretched illegal businesses that would top the list otherwise. If something is legal but only in a particular jurisdiction, then you should only discuss it within the context of the jurisdiction where it is legal.
If it's a grey area, go for it, but extra points for society-harming enterprises definitely legal in both the letter an the spirit of the law.
This is NOT about whether the enterprise in question should be illegal, just whether it causes a net loss of utility (deal with counterfactuals however you see fit).