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Jack comments on What legal ways do people make a profit that produce the largest net loss in utility? - Less Wrong
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This would likely be true of many other (hard) drugs if there had been a history of legally selling them instead of nipping their markets in the bud. In fact, this would probably be true of wireheading too if it was practical, and ultimately, orgasmium. Willing to bite that bullet?
Yes, other drugs are not unmitigated evils either. I've heard heroin is a 1000 times better than sex. The fact that it will eventually kill you and likely ruin your family life doesn't change that. I think alcohol and caffeine probably come out on the positive side of the ledger while most don't. But it is hard to say.