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Jack comments on What legal ways do people make a profit that produce the largest net loss in utility? - Less Wrong
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Yes, other drugs are not unmitigated evils either. I've heard heroin is a 1000 times better than sex. The fact that it will eventually kill you and likely ruin your family life doesn't change that. I think alcohol and caffeine probably come out on the positive side of the ledger while most don't. But it is hard to say.