One possible thing to think about is medical research that targets the diseases that are the most common killers today.
http://www.cdc.gov/nchs/fastats/lcod.htm
Top 2 are heart disease and cancer, followed by lower respiratory infections, strokes, Alzheimer's, and diabetes.
I know it's not really what most of us think about when considering this, but I think that curing those diseases is likely to help us achieve "actuarial escape velocity".
I once heard that a magical cancer cure would extend U.S. life expectancy at birth by three years...
I've recently had the bad luck of having numerous people close to me die. Though I've wanted to contribute to anti-aging and anti-death research for a while, I'm only now in the position of being stable and materially well-off enough to throw around semi-serious cash.
Who should I donate to? I don't want to do anything with cryonics yet; I haven't given cryonics enough thought to be convinced it'd be worth the money. But I was considering the Methuselah foundation.
Suggestions?