Nick_Tarleton comments on Pascal's Mugging: Tiny Probabilities of Vast Utilities - Less Wrong
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Even if there is nobody currently making a bignum-level threat, maybe the utility-maximizing thing to do is to devote substantial resources to search for low-probability, high-impact events and stop or encourage them depending on the utility effect. After all, you can't say the probability of every possibility as bad as killing 3^^^^3 people is zero.