While Nietzsche writes it beautifully, perhaps the simplified, layman version would be:

"If you insist on refusing social obligations and violating social norms, then life becomes very hard: you will be lonely and your conscience will bother you a lot. If you fail---i.e. the pain of being outcast exceeds the benefits of independence---then no one will give a damn."

(The last part is almost tautological; if you're lonely, then most people don't care about you. The exception might be when one writes one's experiences down, as Nietzsche probably did.)