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buybuydandavis comments on What steep learning curve do you wish you'd climbed sooner? - Less Wrong
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One thing I'd add to the list of Aging factors is a generalization on the unnecessary tension and lack of sensation noted by somatic practitioners - feedback loops and signal transduction pathways pegged into insensitive operating points.
Some signal gets too large, which tamps some sensitivity down, when then leads to positive feedback making the original signal even larger. Hormones, neurotransmitters, muscle actuation/sensing. System compensation helps in the short run, but they lead to getting trapped at suboptimal operating points that are local minima, that require some "kick" to get you out.
With the latest post on Neoreactionaries, I felt the urge for some Moldbuggery.
He had an example of the human organizational version of the principle described above, which I realize now is largely his whole Cathedral analysis as well. When the feedback loops get screwed, so do you.