I'm really curious as to where you're getting the $500B number from. I felt like I didn't understand this argument very well at all, and I'm wondering what sorts of results you're imagining as a result of such a program.
It's worth noting that 1E30-1E40 is only the cost of simulating the neurons, and an estimate for the computational cost of simulating the fitness function is not given, although it is stated that the fitness function "is typically the most computationally expensive component". So the evaluation of the fitness function (which presumably has to be complicated enough to accurately assess intelligence), isn't even included in that estimate.
It's also not clear to me at least that simulating neurons is capable of recapitulating the evolution of general intelligence. I don't believe it is a property of individual neurons that causes the brain to be divided into two hemispheres. I don't know anything about brains, but I've never heard of left neurons or right neurons. So is it the neurons that are supposed to be mutating or some unstated variable that describes the organization of the various neurons. If the latter, then what is the computational cost associated with that super structure?
I feel like "recapitulating evolution" is a poor term for this. It's not clear that there's a lot of overlap between this sort of massive genetic search and actual evolution. It's not clear that computational cost is the limiting factor. Can we design a series of fitness functions capable of guiding a randomly evolving algorithm to some sort of general intelligence? For humans, it seems that the mixture of cooperation and competition with other equally intelligent humans resulted in some sort of intelligence arms race, but the evolutionary fitness function that led to humans, or to the human ancestors isn't really known. How do you select for an intelligent/human like niche in your fitness function? What series of problems can you create that will allow general intelligence to triumph over specialized algorithms?
Will the simulated creatures be given time to learn before their fitness is evaluated? Will learning produce changes in neural structure? Is the genotype/phenotype distinction being preserved? I feel like it's almost misleading to include numerical estimates for the computational cost of what is arguably the easiest part of this problem without addressing the far more difficult theoretical problem of devising a fitness landscape that has a reasonable chance to produce intelligence. I'm even more blown away by the idea that it would be possible to estimate a cash value to any degree of precision for such a program. I have literally no idea what the probability distribution of possible outcomes for such a program would be. I don't even have a good estimate of the cost or the theory behind the inputs.
This is part of a weekly reading group on Nick Bostrom's book, Superintelligence. For more information about the group, and an index of posts so far see the announcement post. For the schedule of future topics, see MIRI's reading guide.
Welcome. This week we discuss the third section in the reading guide, AI & Whole Brain Emulation. This is about two possible routes to the development of superintelligence: the route of developing intelligent algorithms by hand, and the route of replicating a human brain in great detail.
This post summarizes the section, and offers a few relevant notes, and ideas for further investigation. My own thoughts and questions for discussion are in the comments.
There is no need to proceed in order through this post. Feel free to jump straight to the discussion. Where applicable, page numbers indicate the rough part of the chapter that is most related (not necessarily that the chapter is being cited for the specific claim).
Reading: “Artificial intelligence” and “Whole brain emulation” from Chapter 2 (p22-36)
Summary
Intro
Whole brain emulation
Notes
Bostrom and Müller's survey asked participants to compare various methods for producing synthetic and biologically inspired AI. They asked, 'in your opinion, what are the research approaches that might contribute the most to the development of such HLMI?” Selection was from a list, more than one selection possible. They report that the responses were very similar for the different groups surveyed, except that whole brain emulation got 0% in the TOP100 group (100 most cited authors in AI) but 46% in the AGI group (participants at Artificial General Intelligence conferences). Note that they are only asking about synthetic AI and brain emulations, not the other paths to superintelligence we will discuss next week.
Omohundro suggests advanced AIs will tend to have important instrumental goals in common, such as the desire to accumulate resources and the desire to not be killed.
Anthropic reasoning
‘We must avoid the error of inferring, from the fact that intelligent life evolved on Earth, that the evolutionary processes involved had a reasonably high prior probability of producing intelligence’ (p27)
Whether such inferences are valid is a topic of contention. For a book-length overview of the question, see Bostrom’s Anthropic Bias. I’ve written shorter (Ch 2) and even shorter summaries, which links to other relevant material. The Doomsday Argument and Sleeping Beauty Problem are closely related.
Whole Brain Emulation: A Roadmap is an extensive source on this, written in 2008. If that's a bit too much detail, Anders Sandberg (an author of the Roadmap) summarises in an entertaining (and much shorter) talk. More recently, Anders tried to predict when whole brain emulation would be feasible with a statistical model. Randal Koene and Ken Hayworth both recently spoke to Luke Muehlhauser about the Roadmap and what research projects would help with brain emulation now.
Levels of detail
As you may predict, the feasibility of brain emulation is not universally agreed upon. One contentious point is the degree of detail needed to emulate a human brain. For instance, you might just need the connections between neurons and some basic neuron models, or you might need to model the states of different membranes, or the concentrations of neurotransmitters. The Whole Brain Emulation Roadmap lists some possible levels of detail in figure 2 (the yellow ones were considered most plausible). Physicist Richard Jones argues that simulation of the molecular level would be needed, and that the project is infeasible.
Other problems with whole brain emulation
Sandberg considers many potential impediments here.
Order matters for brain emulation technologies (scanning, hardware, and modeling)
Bostrom points out that this order matters for how much warning we receive that brain emulations are about to arrive (p35). Order might also matter a lot to the social implications of brain emulations. Robin Hanson discusses this briefly here, and in this talk (starting at 30:50) and this paper discusses the issue.
What would happen after brain emulations were developed?
We will look more at this in Chapter 11 (weeks 17-19) as well as perhaps earlier, including what a brain emulation society might look like, how brain emulations might lead to superintelligence, and whether any of this is good.
Scanning (p30-36)

‘With a scanning tunneling microscope it is possible to ‘see’ individual atoms, which is a far higher resolution than needed...microscopy technology would need not just sufficient resolution but also sufficient throughput.’
Here are some atoms, neurons, and neuronal activity in a living larval zebrafish, and videos of various neural events.
Array tomography of mouse somatosensory cortex from Smithlab.
A molecule made from eight cesium and eight
iodine atoms (from here).
Efforts to map connections between neurons
Here is a 5m video about recent efforts, with many nice pictures. If you enjoy coloring in, you can take part in a gamified project to help map the brain's neural connections! Or you can just look at the pictures they made.
The C. elegans connectome (p34-35)

As Bostrom mentions, we already know how all of C. elegans’ neurons are connected. Here's a picture of it (via Sebastian Seung):
In-depth investigations
If you are particularly interested in these topics, and want to do further research, these are a few plausible directions, some taken from Luke Muehlhauser's list:
How to proceed
This has been a collection of notes on the chapter. The most important part of the reading group though is discussion, which is in the comments section. I pose some questions for you there, and I invite you to add your own. Please remember that this group contains a variety of levels of expertise: if a line of discussion seems too basic or too incomprehensible, look around for one that suits you better!
Next week, we will talk about other paths to the development of superintelligence: biological cognition, brain-computer interfaces, and organizations. To prepare, read Biological Cognition and the rest of Chapter 2. The discussion will go live at 6pm Pacific time next Monday 6 October. Sign up to be notified here.