gjm comments on Group Rationality Diary, October 1-15 - Less Wrong

4 Post author: therufs 30 September 2014 07:34PM

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Comment author: Dahlen 01 October 2014 02:48:19AM *  8 points [-]
  • I got into the habit of doing a quick web search for just about anything for purposes such as finding out more about something (to keep myself from letting an inaccurate idea/cached thought inform my view on the matter), checking internet consensus on the best ways to go about solving common problems, checking whether I'm right or wrong on a factual belief, and many others. It may not sound like much of an improvement in rationality, but I learned loads during the last few days half spent googling random things. (By the way, I probably wouldn't have done this out of the inconvenience of turning on my desktop PC until now; I recently got myself a tablet.)

    • As a result, I learned pretty much all I needed, within reason, in order to fix my diet and workout program. I stopped eating crap entirely, cold turkey; filled my fridge only with the most nutritious foods I know of; began to restrict my calorie count to resting metabolic rate level to ensure I never have to deal with unwanted weight gain again (although I'm not sure yet whether this provides the life extension benefits of calorie restriction); optimized my workouts for maximum fat burning along with an increase in lean body mass and am currently trying to figure out a way around joint pain caused by running a lot. The results are... pretty shocking for someone who hasn't seen me in a long time. ;)

    • Finally did something about my suspected dopamine deficit. For years I've been trying out all sorts of methods for increasing my motivation and productivity, with no avail, because I simply could never muster enough will to get stuff done, my natural inclination being to just laze around all day long. Then I found out about MAO-Is and how they work, and started popping the only over-the-counter supplements that contained MAO-Is that I had around. (I doubt I could have gotten a prescription for anything else; the doctor I've spoken to regarding my dopamine levels recommended me no medication whatsoever.)

I wasn't looking for the non-selective kind, only MAO-B inhibitors interested me, since I couldn't say I was feeling particularly low on serotonin. They unexpectedly came in handy. I recently had something happen to me that would have left me a total wreck otherwise (indeed, similar events in the past did leave me a total wreck); the antidepressant effect was the only reason why I kept feeling basically normal on an affective level. (On a behavioral level, though, I couldn't help acting like a depressed person. That's the only problem I've been noticing so far; your emotions get out of sync with your behavior, and you can't predict yourself anymore.)

Memory has improved; I kept having episodes of random recall. No more brain fog as well; I'm more alert and aware of my surroundings. As for the intended effect... I definitely have a lower "activation energy" now; at last I notice myself starting to study spontaneously, without a lot of inner conflict, anguish and reluctance about the matter. However, it may take a higher dosage for me to have the crazy levels of motivation that my study schedule would require; last night, for instance, after taking my usual MAO-I dosage, I went out with some people and smoked a little (yes, yes, I know...). Now, cigarettes also contain MAO-Is along with nicotine, and apparently that's what makes them so addictive; there are certain warnings when combining two MAO-Is. When I got back home, I began feeling a little over-stimulated. I was energetic as hell and very responsive to any idea that came to me. It would occur to me to do things that I'm normally unenthusiastic about, and my mind would go all "Why, that's a great idea, let's do it!". If the effect lasted a little longer, I might have gotten much more done.

The bottom line, they helped, and they helped a great deal. To everybody who's been trying for a long time to improve motivation and tried everything from Pomodoros to precommitment to psychotherapy: please please please consider dopaminergics. It may have been your core issue all along. There's no substitute for naturally feeling like doing a lot of stuff, and no software (psychological hacks) that can get shoddy hardware (neurochemistry) to run like a supercomputer. Once you do, you may regret not having done it earlier.

  • On an unrelated note: ever since I completed CFAR's sunk cost fallacy exercise book, I don't think I've fallen prey to that bias (that I know of). I now recognize it very easily and tried to give some friends the intuition behind why it is irrational.
Comment author: gjm 01 October 2014 01:33:17PM 5 points [-]

Please be aware (I bet you are, since you say you've researched it, but some other people reading this may not be) that there are some nasty interactions between MAOIs and alcohol, and I think even between MAOIs and some ordinary foods.

Comment author: Dahlen 01 October 2014 04:29:20PM *  4 points [-]

I thought about that, but my ordinary state is the very opposite of the negative side effects caused by excess of serotonin, norepinephrine or dopamine. With too little MAO-A it's serotonin syndrome or hypertensive crisis, whereas I err more on the side of cardio-induced bradycardia, and can withstand a moderate raise in heart rate. (A few days ago I even had dangerously low tension, barely any pulse.) The foods in question are most diary, aged cheese (see "cheese effect)", aged beverages, yoghurt, soy, avocados, some beans and any such stuff high in tyramine (so basically, sucks if you're French). I've consumed some of these with no noticeable effect, but I'm in no position to say that people who are, well, not me can also do so safely.

Alcohol + MAO-Is seems to lead to mild mania for me in the short term, and I'm talking small quantities. I basically never had episodes of mania otherwise. Still no high blood pressure though. It wasn't the worst experience in the world, but whoever wants to stay firmly on the safe side should avoid drinking anything more than a few sips. And anyway, getting piss drunk is out of the question and never a good idea, with or without MAO-Is.

I haven't been taking these for a long time, so I'm still (cautiously) experimenting with the changes they produce.