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Florian_Dietz comments on question: the 40 hour work week vs Silicon Valley? - Less Wrong
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I suspect that being young and having a high IQ (which is correlated with good health) raises the number of hours you should work if your goal is to maximize output. Plus, Modafinil, Adderall, and caffeine probably play a role here.
I also think that is a possibility, especially the first part, but so far I couldn't find any data to back this up.
As for drugs, I am not certain if boosting performance directly, as these drugs do, also affects the speed with which the brain recuperates from stress, which is the limiting factor in why 40 hour weeks are supposed to be good. I suspect that it will be difficult to find an unbiased study on this.
Adderall reduced my need for sleep.