I wondered about this too before I tried it. I thought I had a higher-than-average risk of being very sensitive to my own perspirations/sheddings. But I haven't detected any significant problems on this front after trying it. It goes both ways: Now I know that I'm not very sensitive to my own trouser sweat, it means I can wear trousers longer after they've been washed (i.e. exposed to potentially irritant laundry products), which possibly reduces the risk of skin problems from the laundry products (another problem that I think I have a higher-than-average chance of having; the two aren't mutually exclusive).

(Insert disclaimer about this maybe being very dependent on lots of factors, e.g. maybe I'll move to another city with an imperceptibly different climate and get screwed over by wearing jeans for more than a day.)