The main problem I've had with it is that a too-large dose makes me feel sleepy the next day. (3mg, felt extremely sleepy for 4 hours after getting up, and I'd slept in a bit more than normal, too.) My results are a bit strange, though, because another medication I take interacts with it. 1/4mg (guesstimated by cutting the pills with a knife) is usually enough for me.