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drethelin comments on Low Hanging fruit for buying a better life - Less Wrong
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100 dollars will buy you a good supply of Modafinil, which I strongly recommend using at the beginning of days when you are tired but expect to do a lot of things, or still want to be able to have fun if you missed a night's sleep the day before an event. I've also noticed some anti-depressant effects but that's much less well supported.
Where do you get your modafinil?
I got it something over a year ago, from a now defunct website, unfortunately.