Real physics is local. The graphs, to the extent that there are any, are embedded in metric spaces, have small upper bounds on the number of edges per vertex, are planar, .... generally there is plenty of exploitable structure beyond the pure graph-theoretical problem. This is why I do not think hardness results on abstract graph-theoretical problems will be a great obstacle for practical problems.
Real physics is local, but many practical problems require understanding how the local aspects interact. Consider for example the traveling salesman: this is a purely local problem in statement, but many versions or variants of it occur in practical contexts where actually solving hard instances matters. For example, the bottleneck version shows up in circuit board design. Similarly, graph bandwith is "local" in nature but shows up in chip design, and tough instances do show up in practice. Similarly the pathwidth probem has practical applicatio...
I am not a computer scientist and do not know much about complexity theory. However, it's a field that interests me, so I occasionally browse some articles on the subject. I was brought to https://www.simonsfoundation.org/mathematics-and-physical-science/approximately-hard-the-unique-games-conjecture/ by a link on Scott Aaronson's blog, and read the article to reacquaint myself with the Unique Games Conjecture, which I had partially forgotten about. If you are not familiar with the UGC, that article will explain it to you better than I can.
One phrase in the article stuck out to me: "there is some number of colors k for which it is NP-hard (that is, effectively impossible) to distinguish between networks in which it is possible to satisfy at least 99% of the constraints and networks in which it is possible to satisfy at most 1% of the constraints". I think this sentence is concerning for those interested in the possibility of creating FAI.
It is impossible to perfectly satisfy human values, as matter and energy are limited, and so will be the capabilities of even an enormously powerful AI. Thus, in trying to maximize human happiness, we are dealing with a problem that's essentially isomorphic to the UGC's coloring problem. Additionally, our values themselves are ill-formed. Human values are numerous, ambiguous, even contradictory. Given the complexities of human value systems, I think it's safe to say we're dealing with a particularly nasty variation of the problem, worse than what computer scientists studying it have dealt with.
Not all specific instances of complex optimization problems are subject to the UGC and thus NP hard, of course. So this does not in itself mean that building an FAI is impossible. Also, even if maximizing human values is NP hard (or maximizing the probability of maximizing human values, or maximizing the probability of maximizing the probability of human values) we can still assess a machine's code and actions heuristically. However, even the best heuristics are limited, as the UGC itself demonstrates. At bottom, all heuristics must rely on inflexible assumptions of some sort.
Minor edits.