Thanks. Interesting. I think one issue is maintaining the will to live indefinitely, not getting tired of life, of cumulative stress, basically anti-depresison. I think it would be more useful to focus on fixing that, and when everybody totally wants to live on and on and on, then that generates motivation to throw more resources on anti-aging. Without that, there is a lesser motivation, as people who are not very happy, like myself, will not support it vigorously. Senescence is an acceptable, honorable, non-shameful way of slow suicide, suitable if you are only lightly depressed. You can get old and die without ever having to admit you are depressed or you want to die. If life is extended, you basically either have to endure it longer, or have to own up to, admit defeat, admit you fail at life, and choose suicide. Neither are very attractive options. This is why I recommend fixing the will to live i.e. light depression first.
Fixing the will to live is not going to be easy because it goes against the logic of evolution (which does not care if you are depressed or dead after you have reproduced) and much of human biology. You essentially want to keep people in a constant "expecting rewards" mindset, biologically speaking. In a look forward to tomorrow because something cool with happen mindset. However, it is likely that would lead to some kind of burnout, like, dopamine receptors becoming desensitized from over-use or something like that. Fixing this would be a major brain rewiring.
Hm. This was eye opening enough that I felt like commenting for the first time in a year. I've known for a while about people being too despaired to desire living on, but this puts it under a new perspective.
Most importantly it helps explain the huge discrepancy between how instrumentally important staying alive and able is for anyone who has any goal at all (barring some fringe cases), and how little most people do to plan and organize themselves in order to avoid aging and dying, even as it is reasonably expected to be unavoidable with our current means...
Past and Present
Ten years ago teenager me was hopeful. And stupid.
The world neglected aging as a disease, Aubrey had barely started spreading memes, to the point it was worth it for him to let me work remotely to help with Metuselah foundation. They had not even received that initial 1,000,000 donation from an anonymous donor. The Metuselah prize was running for less than 400,000 if I remember well. Still, I was a believer.
Now we live in the age of Larry Page's Calico, 100,000,000 dollars trying to tackle the problem, besides many other amazing initiatives, from the research paid for by Life Extension Foundation and Bill Faloon, to scholars in top universities like Steve Garan and Kenneth Hayworth fixing things from our models of aging to plastination techniques. Yet, I am much more skeptical now.
Individual risk
I am skeptical because I could not find a single individual who already used a simple technique that could certainly save you many years of healthy life. I could not even find a single individual who looked into it and decided it wasn't worth it, or was too pricy, or something of that sort.
That technique is freezing some of your cells now.
Freezing cells is not a far future hope, this is something that already exists, and has been possible for decades. The reason you would want to freeze them, in case you haven't thought of it, is that they are getting older every day, so the ones you have now are the youngest ones you'll ever be able to use.
Using these cells to create new organs is not something that may help you if medicine and technology continue progressing according to the law of accelerating returns in 10 or 30 years. We already know how to make organs out of your cells. Right now. Some organs live longer, some shorter, but it can be done - for instance to bladders - and is being done.
Hope versus Reason
Now, you'd think if there was an almost non-invasive technique already shown to work in humans that can preserve many years of your life and involves only a few trivial inconveniences - compared to changing diet or exercising for instance- the whole longevist/immortalist crowd would be lining up for it and keeping back up tissue samples all over the place.
Well I've asked them. I've asked some of the adamant researchers, and I've asked the superwealthy; I've asked the cryonicists and supplement gorgers; I've asked those who work on this 8 hour a day every day, and I've asked those who pay others to do so. I asked it mostly for selfish reasons, I saw the TEDs by Juan Enriquez and Anthony Atala and thought: hey look, clearly beneficial expected life length increase, yay! let me call someone who found this out before me - anyone, I'm probably the last one, silly me - and fix this.
I've asked them all, and I have nothing to show for it.
My takeaway lesson is: whatever it is that other people are doing to solve their own impending death, they are far from doing it rationally, and maybe most of the money and psychology involved in this whole business is about buying hope, not about staring into the void and finding out the best ways of dodging it. Maybe people are not in fact going to go all-in if the opportunity comes.
How to fix this?
Let me disclose first that I have no idea how to fix this problem. I don't mean the problem of getting all longevists to freeze their cells, I mean the problem of getting them to take information from the world of science and biomedicine and applying it to themselves. To become users of the technology they are boasters of. To behave rationally in a CFAR or even homo economicus sense.
I was hoping for a grandiose idea in this last paragraph, but it didn't come. I'll go with a quote from this emotional song sung by us during last year's Secular Solstice celebration