Thanks. Interesting. I think one issue is maintaining the will to live indefinitely, not getting tired of life, of cumulative stress, basically anti-depresison. I think it would be more useful to focus on fixing that, and when everybody totally wants to live on and on and on, then that generates motivation to throw more resources on anti-aging. Without that, there is a lesser motivation, as people who are not very happy, like myself, will not support it vigorously. Senescence is an acceptable, honorable, non-shameful way of slow suicide, suitable if you are only lightly depressed. You can get old and die without ever having to admit you are depressed or you want to die. If life is extended, you basically either have to endure it longer, or have to own up to, admit defeat, admit you fail at life, and choose suicide. Neither are very attractive options. This is why I recommend fixing the will to live i.e. light depression first.

Fixing the will to live is not going to be easy because it goes against the logic of evolution (which does not care if you are depressed or dead after you have reproduced) and much of human biology. You essentially want to keep people in a constant "expecting rewards" mindset, biologically speaking. In a look forward to tomorrow because something cool with happen mindset. However, it is likely that would lead to some kind of burnout, like, dopamine receptors becoming desensitized from over-use or something like that. Fixing this would be a major brain rewiring.