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skeptical_lurker comments on Harry Potter and the Methods of Rationality discussion thread, February 2015, chapters 105-107 - Less Wrong
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By all rights, Volde should be an inbred retard, not a genius dark lord.
That's not how inbreeding works, though... If one of your parents' family (in Voldie's case, his mother) has been inbred for generations but the other parents has a completely different gene pool, then you should be fine. Inbreeding just makes it more likely that you have two of the same recessive allelle (which is bad in many situations), but Voldie only got one of each from his mother.
I actually do understand genetics, but I forgot that Voldie had a muggle father. Been a long time since I read canon HP.
Unlike canon, Voldie's father in HPMoR could have lacked magical phenotype, but must have had one magic allele and at least some distant wizard/like ancestors, because of inheritance of magic in HPMOR (which is different from canon). If somebody sequenced the DNA of HPMoR version of Voldie's father, they would find the squib genetic make-up, not muggle.
That is just a side technical note, though. The father was probably sufficiently unrelated to the mother's family, which probably really helped with the inbreeding problems.