Velorien comments on Harry Potter and the Methods of Rationality discussion thread, February 2015, chapter 112 - Less Wrong
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Comments (287)
Transform a grain of sand into a human being, make transformation permanent with Philosopher’s Stone, bring them to life with a defibrillator (which should be sufficient to “create” a muggle, if I understand chapter 111 correctly), kill them to create a horcrux. Sure, from what we know, that should work.
The ethics of creating living humans in order to kill them seconds late are … well, debatable, to put it mildly.
Voldemort refers to sacrificing one person's "life and magic" to preserve another's when describing the horcrux procedure in 108. This suggests that a muggle would not work as a sacrifice.