If those are the unfortunate downsides of policies that are worthwhile overall, then I don't think that qualifies for 'supervillain' status.

I mean, if you're postulating the existence of God, then that also brings up the possibility of an afterlife, etc, so there could well be a bigger picture and higher stakes than threescore years and ten. Sometimes it's rational to say, That is a tragedy, but this course of action is still for the best. Policy debates should not appear one-sided.

If anything, this provides a possible answer to the atheist's question, "Why would God allow suffering?"