I feel stupid. Not for the nanowire, as I was among many who suggested something similar.

I feel stupid for not suggesting the "make Voldemort insane" strategy. I thought it will not work because a wizard's mental state is not necessarily connected to his brain. For example, an animagus transformed into a cat can still retain her human mental state with a cat's brain.

But being driven insane because of a curse might be completely different, and could have an effect not only on the physical brain, but on whatever shape or form the mental state of a wizard is implemented in.