Clarity comments on "Spiritual" techniques that actually work thread - Less Wrong
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Tried Ayahuasca. It works.
Hilarious ayahuasca tourism article on RationalWiki. Convinced me not to go do it, in tandum with warnings around DMT health and safety
Yes there are dangers. Important to read up and have a safe setting. For me the biggest danger is fainting and hitting your head on the ground.
If you are looking for an ayahuasca analogue that is easy to make yourself consider psilohuasca. Just don't do it alone if you have no experience and be careful with the dosage.