ChristianKl comments on The Mr. Hyde of Oxytocin - Less Wrong

4 Post author: theowl 10 May 2015 12:42AM

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Comment author: ChristianKl 10 May 2015 12:21:07PM 1 point [-]

Before using Oxycontin in a job interview I would test it in other settings with lower stakes first.

Nasal Spray Oxycontin doesn't cross the blood brain barrier.

What Oxycontin actually does seems to be that it makes fascia contract. It changes fascia tension patterns in your body. Those matter for emotional management and for how you are perceived by other people. Unfortunately that means the effects are complex and there very little published research on how fascia tension patterns interact with emotions as the psychology department likes to ignore the body and treats it as a black box.

Comment author: PeerGynt 10 May 2015 05:31:29PM *  1 point [-]

Using OxyContin(tm) for a job interview seems like a distinctly bad idea. Particularly if the employer asks for drug screening.. If you absolutely have to, I suggest sticking with Oxytocin.

Comment author: ChristianKl 10 May 2015 06:11:11PM 0 points [-]

I confused the substances and trusted outcomplete when I shouldn't have. But what I said does apply to fascia speak about Oxytocin (my source is the book Anatomy Trains).

As far as the blood brain barrier goes: http://blogs.discovermagazine.com/neuroskeptic/2013/12/08/spinal-taps-save-oxytocin-research/#.VU-dufntlBc

But not everyone does. Some doubt that nasal oxytocin even gets into the brain at all. Oxytocin is a peptide molecule, which means it can’t cross the blood-brain barrier and enter the central nervous system

The timeframe for the effect on fascia seems also to be about right (from Anatomy Trains):

The contraction, when it occurs, comes on very slowly compared to any muscle contraction, building over 20- 30 minutes and sustaining for more than an hour before slowly subsiding.

The neuroskeptic says:

many nasal oxytocin studies use a time delay of 30 or 45 minutes.

Comment author: joaolkf 16 May 2015 06:54:02PM 0 points [-]

I think there is more evidence it crosses (two studies with spinal measures) than it does not (0 studies). For (almost) direct measures check out Neumann, Inga D., et al., 2013 and Born, 2002. There are great many studies showing effects that could only be caused by encephalic neuromodulation. If it does not cross it, then it should cause increased encephalic levels of some neurochemical with the exact same profile, but that would be really weird.