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ChristianKl comments on The Mr. Hyde of Oxytocin - Less Wrong
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I'd be interested in this as well.
I tend to have trust issues, and thought that oxytocin lozenges might make me a little more trusting, and thereby likable, on job interviews.
The premise here seems to be that it would just pump up the paranoia if I have the "anxious attachment style", which seems likely enough.
One example study: http://www.ncbi.nlm.nih.gov/pubmed/25419499
Before using Oxycontin in a job interview I would test it in other settings with lower stakes first.
Nasal Spray Oxycontin doesn't cross the blood brain barrier.
What Oxycontin actually does seems to be that it makes fascia contract. It changes fascia tension patterns in your body. Those matter for emotional management and for how you are perceived by other people. Unfortunately that means the effects are complex and there very little published research on how fascia tension patterns interact with emotions as the psychology department likes to ignore the body and treats it as a black box.
Using OxyContin(tm) for a job interview seems like a distinctly bad idea. Particularly if the employer asks for drug screening.. If you absolutely have to, I suggest sticking with Oxytocin.
I confused the substances and trusted outcomplete when I shouldn't have. But what I said does apply to fascia speak about Oxytocin (my source is the book Anatomy Trains).
As far as the blood brain barrier goes: http://blogs.discovermagazine.com/neuroskeptic/2013/12/08/spinal-taps-save-oxytocin-research/#.VU-dufntlBc
The timeframe for the effect on fascia seems also to be about right (from Anatomy Trains):
The neuroskeptic says:
I think there is more evidence it crosses (two studies with spinal measures) than it does not (0 studies). For (almost) direct measures check out Neumann, Inga D., et al., 2013 and Born, 2002. There are great many studies showing effects that could only be caused by encephalic neuromodulation. If it does not cross it, then it should cause increased encephalic levels of some neurochemical with the exact same profile, but that would be really weird.