Isn't suicide always an option?
Not if you're an upload.
Perhaps it was discussed in more depth before I join LW but I think far, far more cautiousness should be exercised at considering an upload could ever be you.
If you can reduce personhood to information representable in bits, it also means each and any part of it is changeable and replacable, thus there is no lasting essence of individualhood. (My former Buddhist training is really kicking in here, although it is possible I am looking it up in a cache.) Thus there are infinite amount of potential lumps of information, each of which are "more you"...
http://www.theatlantic.com/technology/archive/2015/05/immortal-but-damned-to-hell-on-earth/394160/
With such long periods of time in play (if we succeed), the improbable hellish scenarios which might befall us become increasingly probable.
With the probability of death never quite reaching 0, despite advanced science, death might yet be inevitable.
But the same applies also to a hellish life in the meanwhile. And the longer the life, the more likely the survivors will envy the dead. Is there any safety in this universe? What's the best we can do?