Didn't in one of Iain Banks' books some civilizations run Hells, that is, computer simulations into which they uploaded the sinners (from their point of view) and made eternal hell real for them?
https://en.wikipedia.org/wiki/Surface_Detail
See also Rebecca Roache's discussion of the topic: http://blog.practicalethics.ox.ac.uk/2013/08/enhanced-punishment-can-technology-make-life-sentences-longer/
(Kind of relevant because Ross Ulbricht was just sentenced to maximum charges - two concurrent life sentences and so on - and he's young enough with many favorable demographic traits, 31/white/well-educated/intelligent/fit, that he could easily live another 50 years to 2065, and who knows what will happen by then?)
http://www.theatlantic.com/technology/archive/2015/05/immortal-but-damned-to-hell-on-earth/394160/
With such long periods of time in play (if we succeed), the improbable hellish scenarios which might befall us become increasingly probable.
With the probability of death never quite reaching 0, despite advanced science, death might yet be inevitable.
But the same applies also to a hellish life in the meanwhile. And the longer the life, the more likely the survivors will envy the dead. Is there any safety in this universe? What's the best we can do?