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Romashka comments on Roadmap: Plan of Action to Prevent Human Extinction Risks - Less Wrong
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I really cannot tell. The Irish Famine comes to mind, but surely such things are in the past?.. It's just not a question that you should ask a non-expert if you, because the trivial answer is of course 'yes', but enfolding it takes expertise.
I meant the fungi which kill humans...
IANAD, but there's Pneumocystis pneumonia, a really ugly resistant to treatment thing. Don't know if it's virulent enough to threaten mankind as a whole.
Edit: but considering that the fungus 'appears to be present in healthy individuals in general population' and causes pneumonia if the immune system is weakened, I would not disregard the possibility.