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Romashka comments on Measuredly better than measurably worse: tightening methodology reports - Less Wrong
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Related: from Diabetes Care, v. 38 Supp. 1 jan. 2013, p. 552: Most trials of statins and CVD outcomes tested specific doses against placebo or other statins, rather than aiming for specific LDL [low-density lipoprotein] cholesterol goals...