Elo comments on When does heritable low fitness need to be explained? - Less Wrong

15 Post author: DanArmak 10 June 2015 12:05AM

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Comment author: Elo 11 June 2015 12:39:02AM *  0 points [-]

(2) Empirically, 1/4 of achondroplasia births are inherited and 3/4 are de novo.

sorry; point 2 again, (Aa x aa should product a 1/2 not a 1/4)

acondroplasia X normal

............A.............a

...a.......Aa..........aa

...a......Aa...........aa

50%Aa acondroplasia

50%aa normal

or am I confused somewhere? Is that not the punnet square?

Comment author: Douglas_Knight 11 June 2015 12:51:16AM 0 points [-]

Sure, that's the punnet square. You should stop drawing punnet squares and ask yourself why you are drawing them and ask what role they play.

The number 1/4 is the empirical fitness. It is mainly about how many children dwarfs have. You cannot guess that number by looking at punnet squares.