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I have a problem with how easily people can position themselves as authority figures in social movements which lack competition or standards to vet the candidates. A genuinely capable person might emerge regardless, but more through good luck than through a good process.
For example, Madalyn Murray O'Hair became America's most famous atheist in the 1960's and 1970's because no one else wanted the job, not because she excelled at it compared with competitors. A mediocre but extroverted and opinionated woman willing to take risks could step into the void of the time and assume that title. Even during her life, many other atheists never bought into her cult of personality and considered her a charlatan.
By contrast, in today's world, when many atheists have become minor celebrities, often with best selling books, and when atheists even in hick towns like Tulsa's Seth Andrews can attract followings around the world by setting up websites and uploading podcasts and videos, Madalyn with that kind of competition wouldn't necessarily stand out as particularly noteworthy.
I see a similar situation with today's transhumanist scene. Any newcomer on the make with the right sort of personality (the sort I don't have), willing to exploit social media to present controversial ideas as transhumanist philosophy, could persuade other people into accepting him as a transhumanist authority figure in a relatively short time. It would help if objective standards emerged to assess who deserves this kind of status and who doesn't.
Now, Zoltan Istvan might do something eventually to show that he has the goods. In the meantime I have misgivings about his activities.
How sure are you that O'Hair became the speaker for American atheism because no one else wanted the job rather than because the media focused on her because she was annoying?