You're describing regular Newcomb, not this gene version. (Also note that Omega needs to have more processing power than the programs to do what you want it to do, just like the human version.) The analogue would be defining a short program that Omega will run over the AIs code, that predicts what the AI will output correctly 99% of the time. Then it becomes a question of whether any given AI can outwit the program. If an AI thinks the program won't work on it, for whatever reason (by which I mean "conditioning on myself picking X doesn't cause my estimate of the prediction program outputting X to change, and vice-versa"), it's free to choose whatever it wants to.
Getting back to humans, I submit that a certain class of people that actually think about the problem will induce a far greater failure rate in Omega, and that therefore that severs the causal link between my decision and Omega's, in the same way as an AI might be able to predict that the prediction program won't work on it.
As I said elsewhere, were this incorrect, my position would change, but then you probably aren't talking about "genes" anymore. You shouldn't be able to get 100% prediction rates from only genes.
It should be obvious that there is no difference between regular Newcomb and genetic Newcomb here. I examine the source code to see whether the program will one-box or not; that is the same as looking at its genetic code to see if it has the one-boxing gene.
I am currently learning about the basics of decision theory, most of which is common knowledge on LW. I have a question, related to why EDT is said not to work.
Consider the following Newcomblike problem: A study shows that most people who two-box in Newcomblike problems as the following have a certain gene (and one-boxers don't have the gene). Now, Omega could put you into something like Newcomb's original problem, but instead of having run a simulation of you, Omega has only looked at your DNA: If you don't have the "two-boxing gene", Omega puts $1M into box B, otherwise box B is empty. And there is $1K in box A, as usual. Would you one-box (take only box B) or two-box (take box A and B)? Here's a causal diagram for the problem:
Since Omega does not do much other than translating your genes into money under a box, it does not seem to hurt to leave it out:
I presume that most LWers would one-box. (And as I understand it, not only CDT but also TDT would two-box, am I wrong?)
Now, how does this problem differ from the smoking lesion or Yudkowsky's (2010, p.67) chewing gum problem? Chewing Gum (or smoking) seems to be like taking box A to get at least/additional $1K, the two-boxing gene is like the CGTA gene, the illness itself (the abscess or lung cancer) is like not having $1M in box B. Here's another causal diagram, this time for the chewing gum problem:
As far as I can tell, the difference between the two problems is some additional, unstated intuition in the classic medical Newcomb problems. Maybe, the additional assumption is that the actual evidence lies in the "tickle", or that knowing and thinking about the study results causes some complications. In EDT terms: The intuition is that neither smoking nor chewing gum gives the agent additional information.