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juliawise comments on Experiences in applying "The Biodeterminist's Guide to Parenting" - Less Wrong
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But you can observe that pyrethrins are used on large scale as food. That is why they are so popular as insecticides. I'll take that thousand year observational study over a single fishing expedition.
People also spent a very long time using lead water pipes and drinking vessels made with lead, and apparently didn't notice a problem.
It doesn't surprise me that ant poison isn't great for children.
No, the Romans were aware of the toxicity of lead.
Yet it was used for water pipes into the 20th century. My understanding is that they knew high doses were toxic, but didn't see a problem with low doses.