"Effective" at what? Most websites aren't terribly concerned with aesthetic nuances -- they're concerned with things like monetization, channeling users into specific behaviours, avoiding user confusion, etc.
User interaction / interface design / usability / human-computer interface / etc. is a thriving field.
So I'm working for a friend's company at the moment (friend is a small business owner who designs websites and a bit of an entrepreneur) anyway, I've persuaded him that we should research the empirical literature on what makes websites effective (which we've done a lot of now) and to advertise ourselves as being special by reason of doing this (which we're only just starting to do).
One thing that I found absolutely remarkable is how unfilled this space tends to be. Like a lot of things in the broad area of empirical aesthetics it seems like there are a lot of potentially useful results (c.f.http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3485842/ ), but they're simply not being applied- either as points of real practice or of marketing differentiation.
A fascinating gap.