oge comments on We really need a "cryonics sales pitch" article. - Less Wrong

10 Post author: CronoDAS 03 August 2015 10:42PM

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Comment author: oge 04 August 2015 01:09:59AM 1 point [-]

CronoDAS, I'm glad you brought up this issue. Sadly, I don't think there's good evidence that cryo, as practiced today, works. I think it is reasonable (but of course, not ideal) for people to dismiss things which are only theoretically possible but not practically possible.

If we had verifiably working cryo today, it might be easier to change people's minds.

Comment author: jordansparks 11 August 2015 10:24:45PM 2 points [-]

Cryonics is being deeply confused with suspended animation in this thread. Cryonics has nothing to do with cellular viability. It's only about preserving the wiring and physical structure of the brain by any means necessary. In current cryonics, all cells are totally and completely dead long before the procedure is finished. But we also have electron micrographs showing very good structural preservation of these dead cells. The cryonics revival technology will need to manipulate trillions of atoms inside of each of billions of cells. No low tech is going to be able to revive them.

Comment author: oge 11 August 2015 10:40:25PM 0 points [-]

Thank you for clarifying this point.

FYI I was referring only to "Cryonics" when I said cryo in the parent comment, not to "suspended animation".

Comment author: ike 04 August 2015 01:16:23PM 2 points [-]

If we had verifiably working cryo today, it might be easier to change people's minds.

I think your "might" is a severe understatement. If people could actually see other previously dead people walk, this would have an immediate and large effect.

Comment author: bbleeker 04 August 2015 06:38:15PM 1 point [-]

If they could even just revive a mouse, that'd help a lot already.

Comment author: Error 05 August 2015 04:56:22PM 0 points [-]

What is the largest living thing that has been successfully pulled out of cryo? A single cell? Disconnected tissue? An organ?

I'd find a single cell not terribly convincing, a working organ much more so.

(context: I haven't signed up and don't currently intend to, but it's mentally marked as "keep an eye on this, additional information may change my mind.")

Comment author: AndreInfante 05 August 2015 11:30:58PM 5 points [-]

Technically, it's the frogs and fish that routinely freeze through the winter. Of course, they evolved to pull off that stunt, so it's less impressive.

We've cryopreserved a whole mouse kidney before, and were able to thaw and use it as a mouse's sole kidney.

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2781097/

We've also shown that nematode memory can survive cryopreservation:

http://www.dailymail.co.uk/sciencetech/article-3107805/Could-brains-stay-forever-young-Memories-survive-cryogenic-preservation-study-shows.html

The trouble is that larger chunks of tissue (like, say, a whole mouse or a human brain) are more prone to thermal cracking at very low temperatures. Until we solve that problem, nobody's coming back short of brain emulation or nanotechnology.

Comment author: CBHacking 08 August 2015 09:38:46AM 1 point [-]

Nitpick: The article talks about a rabbit kidney, not a mouse one

It also isn't entirely clear how cold the kidney got, or how long it was stored. It's evidence in favor of "at death" cryonics, but I'm not sure how strong of evidence it is. Also, it's possible to survive with substantially more kidney damage than you would even want to incur as brain damage.

Comment author: Lumifer 05 August 2015 05:02:22PM 1 point [-]

Waterbears routinely survive freeze-thaw cycles (and much more besides).